Toptada 20 MG Tablet relaxes the smooth muscles present in the wall of blood vessels and helps in increasing the flow of blood in certain specific areas of the body. It is used for the treatment of erection disorders, prostate gland enlargement and Pulmonary Hypertension (high blood pressure of blood vessels connecting the lungs and the heart)
Tadalafil is a prescription medication that is used in the management of erectile dysfunction in men suffering from the condition. This medication is similar in its actions to Sildenafil citrate which is another popular brand medication used in the treatment of erectile dysfunction.
Tadalafil generic improves blood inflow into the penis. The greatest benefit of Tadalafil over Sildenafil citrate is its duration of efficacy. The medication produces its actions for a longer duration in comparison with Sildenafil citrate. Due to this increased ability of work, Tadalafil original is many a time referred to as a weekend pill as its effects last for duration of about 36 hours. However, the drug does not work on its own in the absence of sexual arousal.
Tadalafil generic Mechanism of Action
Tadalafil original is a type of drug that is referred to as PDE5 inhibitor. PDE5 is an enzyme that reduces and causes breakdown of another enzyme called cyclic GMP or cGMP. By being a PDE5 inhibitor, Tadalafil original causes improvement of the levels of cGMP. Cyclic GMP is involved in causing smooth muscle relaxation in the cavernous body of the penis through protein interactions. This enables more inflow of blood into the penis facilitating better erection and improving the ability of the person to engage in sexual activity.
Contraindications for Tadalafil generic Use
Tadalafil generic 20mg is not indicated for use if the person has known allergy or hypersensitivity to any constituents of the medication. The medication is also best avoided if the person is experiencing symptoms of angina or is under medication with any form of nitrates to treat the condition. The drug is also not indicated for use in children, adolescents below the age of 18 and in women as the drug safety and efficacy has not been studied.
The use of Tadalafil original must be with extreme caution in persons suffering from any severe form of liver or kidney disorders (below 30ml/min clearance rate of creatinine).
Generic Tadalafil Recommended Dosage
The medication is only intended for oral use. The usual advised dose of Tadalafil original is 20 mg in a day that needs to be taken about half to one hour prior to any sexual activity. Once taken, the person will experience the effects of the medication for about 36 hours. Tadalafil original should not be taken more than once in the duration of a day.
Tadalafil generic 20mg Precautions and Warnings
Any form of sexual activity holds risk for persons suffering from any type of cardiovascular conditions. So, if the person has any type of such conditions, the use of Tadalafil original is not indicated or should be used with extreme caution. Some such conditions wherein the use of the medication should be with caution include:
- A recent history of heart attack in the past 3 months.
- Coronary artery disease
- History of Stroke in the past 6 months
- Unstable stenocardia
The use of Tadalafil original must be with extreme caution in person suffering from any kind of deformations of the penis, priapism and conditions that carry the risk of priapism.
Generic Tadalafil 20mg Adverse Effects
The most commonly seen adverse effects from taking Tadalafil original include dyspepsia and headache. The other adverse effects of taking the medication might include myalgia, hot flashes, back pain and nasal congestion. Some uncommon side effects of Tadalafil might include pain in the eyes, edema in the area of the eyelids, hyperemia in the region of the conjunctiva and dizziness.
- Persistent cough
- Decrease/loss of visionSEVERERARE
- Change in color visionSEVERE
- Decrease/loss of hearingSEVERERARE
- Prolonged and painful erectionSEVERERARE
- Allergic skin reactionRARE
- Difficulty in breathingSEVERE
- Difficulty in swallowing
- Swelling of face, lips, eyelids, tongue, hands and feet SEVERERARE
- Peeling and blistering of skinSEVERERARE
- Upper respiratory tract infectionSEVERE
- Pain in the arms, legs and the back
- Uterine bleeding
Generic Tadalafil Drug Interactions
Tadalafil generic 20mg has the possibility of causing drug interactions if taken concomitantly with other medications such as:
Alpha blockers: The use of alpha blockers concomitantly with the medication has the possibility of leading to severe reduction of blood pressure.
Hypertension Drugs: The use of concomitant Tadalafil with antihypertensive drugs such as Lisinopril has the potential to lead to severe hypotension.
Some medications that get metabolized within the liver such as erythromycin, fluconazole, itraconazole, ketaconazole and rifampicin must not be used concomitantly with Tadalafil original.
The use of Xanthines such as theophylline in combination with Tadalafil should be avoided.
The use of Tadalafil generic 20mg concomitantly with nitrates, donors of nitrogen oxide and medications that are commonly referred to as poppers should be totally avoided due to the risk of causing life threatening complications.
Tadalafil original should not be used if the person is taking medications such as ritonavir or indinavir, which are protease inhibitors.
Alcohol intake and grape juice intake when the person is taking Tadalafil original should be totally avoided.
Tadalafil generic Overdose
It is best to follow the instructions of the doctor while taking Tadalafil generic 20mg. It is best not to take the medication exceeding the dosage advised. If an overdose is taken, it carries the risk of increased side effects. If an overdose is taken, it is best to seek proper medical attention at the earliest.
It is also not advisable to take other PDE5 inhibitors like Sildenafil citrate at the same time when Tadalafil original is being taken. The safety and efficacy of such combinations have not been adequately studied and documented.